• 姓名: 白林泉
  • 职称: 教授
  • 学位: 博士
  • 上海交通大学
  • 生命科学技术学院
教育背景

1992年获得山东大学微生物系学士学位。

1995年获得华中农业大学微生物专业硕士学位。

1998年获得华中农业大学分子生物学专业理学博士学位。

工作经历

1999年至2002年4月在美国华盛顿大学化学系从事博士后研究。

之后回国到上海交通大学生命科学技术学院工作。

2006年至2007年初在德国Tuebingen大学微生物研究所从事生物合成调节方面的合作研究。

论文专著

在PNAS、JACS、NPR、Chemistry &Biology、AEM、Chembiochem等杂志发表50篇研究论文,其中第一作者及通讯作者20篇。研究成果被Nature Biotechnology、Nature China、Faculty of 1000 Biology等专文评价  代表性论文

1.Zheng L, Zhou X, Zhang H, Ji X, Li L, Huang L, Bai L*, Zhang H*. Structural and functional analysis of validoxylamine A 7' -phosphate synthase ValL involved in validamycin A biosynthesis. PLoS One. 2012, 7(2):e32033.

2.Wang B, Kang Q, Lu Y, Bai L, Wang C. Unveiling the biosynthetic puzzle of destruxins in Metarhizium species. Proc Natl Acad Sci U S A. 2012, 109(4):1287-92.

3.Li Y, Zhao P, Kang Q, Ma J, Bai L*, Deng Z. Dual carbamoylations on the polyketide and glycosyl moiety by asm21 result in extended ansamitocin biosynthesis. Chem Biol. 2011, 18(12):1571-80.

4.Kang Q, Shen Y, Bai L*. Biosynthesis of 3,5-AHBA-derived natural products. Nat Prod Rep. 2012, 29(2):243-63.

5.Jiang C, Wang H, Kang Q, Liu J, Bai L*. Cloning and characterization of the polyether salinomycin biosynthesis gene cluster of Streptomyces albus XM211. Appl Environ Microbiol. 2012, 78(4):994-1003.

6.Zhou X, Wu H, Li Z, Zhou X, Bai L*, Deng Z. Over-expression of UDP-glucose pyrophosphorylase increases validamycin A but decreases validoxylamine A production in Streptomyces hygroscopicus var. jinggangensis 5008. Metab Eng. 2011, 13(6):768-76.

7.Kang Q, Bai L*, Deng Z. Toward steadfast growth of antibiotic research in China.From natural products to engineered biosynthesis. Biotechnol Adv. 2011.

8.Qiu J, Zhuo Y, Zhu D, Zhou X, Zhang L, Bai L*, Deng Z. Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis. Appl Microbiol Biotechnol. 2011, 92(2):337-45.

9.Wu Y, Kang Q, Shang G, Spiteller P, Carroll B, Yu TW, Su W, Bai L*, Floss HG. N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis. Chembiochem. 2011, 12(11):1759-66.

10.Wu Y, Kang Q, Shen Y, Su W, Bai L*. Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS. Mol Biosyst. 2011, 7(8):2459-69.

11.Wu Q, Liang J, Lin S, Zhou X, Bai L*, Deng Z, Wang Z*. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin (A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011, 55(3):974-82.

12.He Y, Sun Y, Liu T, Zhou X, Bai L*, Deng Z. Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification. Appl Environ Microbiol. 2010, 76(10):3283-92.

13.Xu H, Zhang Y, Yang J, Mahmud T*, Bai L*, Deng Z. Alternative epimerization in C(7)N-aminocyclitol biosynthesis is catalyzed by ValD, a large protein of the vicinal oxygen chelate superfamily. Chem Biol. 2009, 16(5):567-76.

14.Zhang Y, Bai L*, Deng Z. Functional characterization of the first two actinomycete 4-amino-4-deoxychorismate lyase genes. Microbiology. 2009, 155(Pt 7):2450-9.

15.Zhou Y, Meng Q, You D, Li J, Chen S, Ding D, Zhou X, Zhou H*, Bai L*, Deng Z. Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008. Appl Environ Microbiol. 2008, 74(23):7235-42.

16.Xu H, Yang J, Bai L*, Deng Z, Mahmud T*. Genetically engineered production of 1,1' -bis-valienamine and validienamycin in Streptomyces hygroscopicus and their conversion to valienamine. Appl Microbiol Biotechnol. 2009, 81(5):895-902.

17.Zhao P, Bai L*, Ma J, Zeng Y, Li L, Zhang Y, Lu C, Dai H, Wu Z, Li Y, Wu X, Chen G, Hao X, Shen Y*, Deng Z, Floss HG. Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins. Chem Biol. 2008, 15(8):863-74.

18.Zhang X, Fen M, Shi X, Bai L*, Zhou P*. Overexpression of yeast S-adenosylmethionine synthetase metK in Streptomyces actuosus leads to increased production of nosiheptide. Appl Microbiol Biotechnol. 2008, 78(6):991-5.

19.Minagawa K, Zhang Y, Ito T, Bai L*, Deng Z, Mahmud T. ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A. Chembiochem. 2007, 8(6):632-41.

20.Deng Z, Bai L*. Antibiotic biosynthetic pathways and pathway engineering--a growing research field in China. Nat Prod Rep. 2006, 23(5):811-27.

21.Bai L, Li L, Xu H, Minagawa K, Yu Y, Zhang Y, Zhou X, Floss HG, Mahmud T, Deng Z*. Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A. Chem Biol. 2006, 13(4):387-97.

22.Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG*. The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum. Proc Natl Acad Sci U S A. 2002, 99(12):7968-73.

奖励/荣誉

基金委“ 重要微生物合成与分解代谢的分子机理” 创新研究群体和微生物代谢国家重点实验室研究骨干。

被评为06年“ 中国高等学校十大科技进展” 、07年“ 教育部自然科学二等奖” 和08年“ 国家自然科学二等奖” 。

承担和参加了国家自然科学基金4项及国家863计划项目2项。

07年入选教育部“ 新世纪优秀人才支持计划” ,08年入选上海市教委“ 曙光人才计划” ,09年获得“ 明治乳业生命科学奖” 和“ 第十一届中国青年科技奖” 。