• 姓名: 叶茂
  • 职称: 教授
  • 学位: 博士
  • 湖南大学
  • 生物学院
教育背景
2005年7月毕业于中南大学湘雅医学院肿瘤研究所,获得医学博士学位。
工作经历

2005年8月-2007年3月于浙江省温州医学院卫生部重点实验室,从事肿瘤发病机制研究。

2007年3月-2010年6月于美国纽约Lindsley F. Kimball Research Institute (LFKRI)从事肿瘤分子病理机制的博士后研究工作。

2010年9月-至今于湖南大学生物学院从事分子医学相关的教学和科研工作。

科研项目
主持和参与国家自然科学基金、浙江省自然科学基金、长沙市科技计划等多项,作为co-PI主持美国Rose M.Badgeley Residuary Charitable基金一项。
论文专著
已在Cancer Letters、FEBS Letters、Invest Ophthalmol Vis Sci等杂志发表科研论文多篇,其中两篇文章作为封面文章发表。

1.Sun Y, Cao L, Sheng X, Chen J, Zhou Y, Yang C, Deng T, Ma H, Feng P, Liu J, Tan W*, Ye M*. WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway. Cell Death Dis. 2017 Apr 13;8(4): e2743

2.Yi Y, Wang H, Wang X, Liu Q*, Ye M*, Tan W. A Smart, Photocontrollable Drug Release Nanosystem for Multifunctional Synergistic Cancer Therapy. ACS Appl Mater Interfaces. 2017 Feb 22;9(7):5847-5854

3.Sun, S; Wang, Y; Chen, H; Fang, L; Cui, Y; Han, X; Wu, D; Li, H; Ye, M; Zhao, X*; Liu, J*, STIP regulates ERK1/2 signaling pathway involved in interaction with PP1gamma in lymphoblastic leukemia., Current Molecular Medicine, 2016/10/18.

4.Wang, Zi; Zhang, Jingxin; Zeng, Yayue; Sun, Shuming; Zhang, Ji; Zhang, Bin; Zhu, Min; Ouyang, Ruoyun; Ma, Bianyin; Ye, Mao*; An, Xiuli*; Liu, Jing*, Knockout of 4.1B triggers malignant transformation in SV40T-immortalized mouse embryo fibroblast cells., Molecular Carcinogenesis, 2016/6/17.

5.Mridul Roy, Long Liang, Xiaojuan Xiao, Yuanliang Peng, Yuhao Luo, Weihua Zhou, Ji Zhang, Lugui Qiu, Shuaishuai Zhang, Feng Liu, Mao Ye*, Wen Zhou*, Jing Liu*. Lycorine Inhibits Autophagy and Enhances Bortezomib Activity by Inducing Proteasomal Degradation of HMGB1 in Multiple Myeloma. Theranostics .2016; 6(12):2209-2224

6.Duan, Minlan; Long, Yuqian; Yang, Cai; Wu, Xiaoqiu; Sun, Yang; Li, Jianglin; Hu, Xiaoxiao; Lin, Wei; Han, Dongmei; Zhao, Yifan; Liu, Jing; Ye, Mao*; Tan, Weihong*, Selection and characterization of DNA aptamer for metastatic prostate cancer recognition and tissue imaging., Oncotarget, 2016/5/10.

7.Yuqian Long, Zhiqiang Qin, Minlan Duan, Shizhu Li, Xiaoqiu Wu, Wei Lin, Jianglin Li, Zilong Zhao, Jing Liu, Dehui Xiong, Yi Huang, Xiaoxiao Hu, Chao Yang, Mao Ye* & Weihong Tan*.Screening and identification of DNA aptamers toward Schistosoma japonicum eggs via SELEX. Scientific Reports. 2016; 6:24986.(Corresponding author)

8.Sun, Yang; Yang, Chao; Chen, Jieying; Song, Xin; Li, Zhen; Duan, Minlan; Li, Jianglin; Hu, Xiaoxiao; Wu, Kuangpei; Yan, Guobei; Yang, Cai; Liu, Jing; *Tan, Weihong; *Ye, Mao,Overexpression of WDR79 in non-small cell lung cancer is linked to tumour progression.,Journal of Cellular and Molecular Medicine, 2016/2/5.(corresponding author)

9.Wang, Zi; Ma, Bianyin; Li, Hui; Xiao, Xiaojuan; Zhou, Weihua; Liu, Feng; Zhang, Bin; Zhu, Min; Yang, Qin; Zeng, Yayue; Sun, Yang; Sun, Shuming; Wang, Yanpeng; Zhang, Yibin; Weng, Haibo; Chen, Lixiang; *Ye, Mao; *An, Xiuli; *Liu, Jing,Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC., Oncotarget, 2015/11/13.(Corresponding author).

10.Luo, Yuhao; Roy, Mridul; Xiao, Xiaojuan; Sun, Shuming; Liang, Long; Chen, Huiyong; Fu, Yin; Sun, Yang; Zhu, Min; Ye, Mao; Liu, Jing,Lycorine induces programmed necrosis in the multiple myeloma cell line ARH-77., Tumor Biology, 36(4), pp 2937-2945, 2015/4.

11.*Ye, Mao; Tang, Yani; Tang, Shijun; Liu, Jing; Wu, Kuangpei; Yao, Shan; Sun, Yang; Zhou, Lei; Deng, Tanggang; Chen, Ying; Huang, Chenghan; *Tan, Weihong,STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation., Oncotarget, 6(33), pp 34718-34731, 2015/10/27. (Corresponding author)

12.Tang, Yani; Yan, Guobei; Song, Xin; Wu, Kuangpei; Li, Zhen; Yang, Chao; Deng, Tanggang; Sun, Yang; Hu, Xiaoxiao; Yang, Cai; Bai, Huarong; Li, Hui; Tan, Weihong; *Ye, Mao; *Liu, Jing,STIP overexpression confers oncogenic potential to human non-small cell lung cancer cells by regulating cell cycle and apoptosis., Journal of Cellular and Molecular Medicine, 2015/9/10. (Corresponding author).

13.Zhu, Huijie; Li, Jin; Zhang, Xiao-Bing; Ye, Mao; Tan, Weihong,Nucleic acid aptamer-mediated drug delivery for targeted cancer therapy., ChemMedChem, 10(1), pp 39-45, 2015/1.

14.Wu, Xiaoqiu; Zhao, Zilong; Bai, Huarong; Fu, Ting; Yang, Chao; Hu, Xiaoxiao; Liu, Qiaoling; Champanhac, Carole; Teng, I-Ting; *Ye, Mao; *Tan, Weihong,DNA Aptamer Selected against Pancreatic Ductal Adenocarcinoma for in vivo Imaging and Clinical Tissue Recognition., Theranostics, 5(9), pp 985-994, 2015. (Corresponding author)

15.Wang, Zi; Zhang, Ji; Ye, Mao; Zhu, Min; Zhang, Bin; Roy, Mridul; Liu, Jing; An, Xiuli,Tumor suppressor role of protein 4.1B/DAL-1., Cellular and Molecular Life Sciences, 71(24), pp 4815-4830, 2014/12.(Co-first author). IF:5.81

16.Hu, Jun; Zhao, Zilong; Liu, Qiaoling; Ye, Mao; Hu, Bingqiang; Wang, Jing; *Tan, Weihong,Study of the Function of G-Rich Aptamers Selected for Lung Adenocarcinoma., Chem Asian J, 10(7), pp 1519-1525, 2015/7.

17.Roy, Mridul; Luo, Yu-Hao; *Ye, Mao; *Liu, Jing,Nonsmall Cell Lung Cancer Therapy: Insight into Multitargeted Small-Molecule Growth Factor Receptor Inhibitors, BIOMED RESEARCH INTERNATIONAL, 2013卷, pp 1-11, 2013/7/1.(Corresponding author)

18.Wang, RuoWen; Zhu, Guizhi; Mei, Lei; Xie, Yan; Ma, Haibin; Ye, Mao; Qing, Feng-Ling; *Tan, Weihong,Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery, Journal of the American Chemical Society, 136(7), pp 2731-2734, 2014/2/19.

19.Dai, Hongjuan; Ye, Mao; Peng, Mingyuan; Zhou, Weihua; Bai, Huarong; Xiao, Xiaojuan; Ma, Bianying; Zhou, Jiajie; Tang, Shijun; Yao, Shan; Cao, Ye; Qin, Zhiqiang; Liu, Jing; Tan, Weihong,Aptamer TY04 inhibits the growth of multiple myeloma cells via cell cycle arrest., Tumor Biology, 35(8), pp 7561-7568, 2014/8. (Co-first author)

20.Li, Lv; Dai, Hong-Juan; *Ye, Mao; Wang, Shu-Ling; Xiao, Xiao-Juan; Zheng, Jie; Chen, Hui-Yong; Luo, Yu-hao; Liu, Jing,Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition, Cancer Cell International, 12卷, 2012/11/23.(Corresponding author).

21.Peng, Lu; Wu, Cuichen Sam; You, Mingxu; Han, Da; Chen, Yan; Fu, Ting; *Ye, Mao; *Tan, Weihong,Engineering and applications of DNA-grafted polymer materials, Chemical Science, 4(5), pp 1928-1938, 2013. (Corresponding author).

22.Wang, Hui; Donovan, Michael J.; Meng, Ling; Zhao, Zilong; Kim, Youngmi; Ye, Mao; *Tan, Weihong,DNAzyme-Based Probes for Telomerase Detection in Early-Stage Cancer Diagnosis, Chemistry - A European Journal, 19(14), pp 4633-4639, 2013/4.

23.*Ye, Mao; Hu, Jun; Peng, Minyuan; Liu, Jing; Liu, Jun; Liu, Huixia; Zhao, Xielan; *Tan, Weihong,Generating Aptamers by Cell-SELEX for Applications in Molecular Medicine, International Journal of Molecular Sciences, 13(3), pp 3341-3353, 2012/3. (Corresponding author).

24.Zhu, Guizhi; Meng, Ling; Ye, Mao; Yang, Liu; Sefah, Kwame; O'Donoghue, Meghan B.; Chen, Yan; Xiong, Xiangling; Huang, Jin; Song, Erqun; *Tan, Weihong,Self-Assembled Aptamer-Based Drug Carriers for Bispecific Cytotoxicity to Cancer Cells, Chemistry-An Asian Journal, 7(7), pp 1630-1636, 2012/6.

25.Zhu, Guizhi; *Ye, Mao; Donovan, Michael J.; Song, Erqun; Zhao, Zilong; *Tan, Weihong,Nucleic acid aptamers: an emerging frontier in cancer therapy, Chemical Communications, 48(85), pp 10472-10480, 2012. (Corresponding author).

26.*Zhang, Kejing; Sefah, Kwame; Tang, Lili; Zhao, Zilong; Zhu, Guizhi; Ye, Mao; Sun, Weijia; Goodison, Steve; Tan, Weihong,A Novel Aptamer Developed for Breast Cancer Cell Internalization, ChemMedChem, 7(1), pp 79-84, 2012/1/2.

27.Ding, L; Li, LL; Yang, J; Tao, YG; Ye, M; Shi, Y; Tang, M; Yi, W; Li, XL; *Gong, JP,Epstein-Barr virus encoded latent membrane protein 1 modulates nuclear translocation of telomerase reverse transcriptase protein by activating nuclear factor-kappa B p65 in human nasopharyngeal carcinoma cells, International Journal of Biochemistry & Cell Biology, 37(9), pp 1881-1889, 2005/9.

28.*Wu Wencan; Ye Mao; Yan Wentao; Lu Fan; Qu Jia; Wang Qinmei; Zhou Xiangtian,Using basement membrane of human amniotic membrane as a cell carrier for cultivated cat corneal endothelial cell transplantation, Current Eye Research, 32(3), pp 199-215, 2007.

29.Ye, Mao; Luo, Xiangjian; Li, Lili; Shi, Ying; Tan, Ming; Weng, Xinxian; Li, Wei; Liu, Jikai; *Cao, Ya,Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway, Cancer Letters, 258(2), pp 199-207, 2007/12/18.

30.Ye, Mao; Hu, Danning; Tu, Lili; Zhou, Xiangtian; Lu, Fan; Wen, Bin; Wu, Wencan; Lin, Yi; *Zhou, Zhonglou; Qu, Jia,Involvement of PI3K/Akt signaling pathway in hepatocyte growth factor - induced migration of uveal melanoma cells, Investigative Ophthalmology & Visual Science, 49(2), pp 497-504, 2008/2. (corresponding author)

31.Huang, Cheng-Han; Ye, Mao,The Rh protein family: gene evolution, membrane biology, and disease association, Cellular and Molecular Life Sciences, 67(8), pp 1203-1218, 2010/4.

32.Kong RongMei; Chen Zhuo; Ye Mao; *Zhang XiaoBing; Tan WeiHong,Cell-SELEX-based aptamer-conjugated nanomaterials for enhanced targeting of cancer cells, Science China Chemistry, 54(8), pp 1218-1226, 2011/8.

33.Liu, Jun; You, Mingxu; Pu, Ying; *Liu, Huixia; Ye, Mao; Tan, Weihong,Recent Developments in Protein and Cell-Targeted Aptamer Selection and Applications, Current Medicinal Chemistry, 18(27), pp 4117-4125, 2011/9.

34.Yang, Liu; *Zhang, Xiaobing; Ye, Mao; Jiang, Jianhui; Yang, Ronghua; Fu, Ting; Chen, Yan; Wang, Kemin; Liu, Chen; Tan, Weihong,Aptamer-conjugated nanomaterials and their applications, Advanced Drug Delivery Reviews, 63(14-15), pp 1361-1370, 2011/11.

35.Lu, ZX; Ye, M; Yan, GR; Li, Q; Tang, M; Lee, LM; *Sun, LQ; Cao, Y,Effect of EBV LMP1 targeted DNAzymes on cell proliferation and apoptosis, Cancer Gene Therapy, 12(7), pp 647-654, 2005/7.

36.Liu, J; *Hu, WX; He, LF; Ye, M; Li, Y,Effects of lycorine on HL-60 cells via arresting cell cycle and inducing apoptosis, FEBS Letters, 578(3), pp 245-250, 2004/12/17.

37.Ye, M; *Liu, JK; Lu, ZX; Zhao, Y; Liu, SF; Li, LL; Tan, M; Weng, XX; Li, W; Cao, Y,Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro, FEBS Letters, 579(16), pp 3437-3443

38.Zhao, Y; Yang, LF; Ye, M; Gu, HH; *Cao, Y,Induction of apoptosis by epigallocatechin-3-gallate via mitochondrial signal transduction pathway, Preventive Medicine, 39(6), pp 1172-1179, 2004/12.

39.Minlan Duan, Yuqian Long, Cai Yang, Xiaoqiu Wu, Yang Sun, Jianglin Li, Xiaoxiao Hu, Wei Lin, Dongmei Han, Yifan Zhao, Jing Liu, Mao Ye*, Weihong Tan*.Protein Selection and characterization of DNA aptamer for metastatic prostate cancer recognition and tissue imaging., Oncotarget, 2016/05/10.(Corresponding author).

专利成果
申请国内发明专利一项,美国专利两项。
奖励/荣誉

获得湖南省2010自然科学一等奖(第六)、教育部2009年度高等学校科学研究优秀成果(自然科学奖)二等奖(第七)、温州市第十三届自然科学优秀论文一等奖各一项。

2006年入选温州市“新世纪551人才工程”第二层次培养人选。

2007年入选浙江省高校中青年学科带头人培养对象。

2013年入选教育部新世纪优秀人才。