• 姓名: 王洪辉
  • 职称: 副教授
  • 学位: 博士
  • 湖南大学
  • 生物学院
教育背景

2002年获南开大学微生物学学士学位;

2009年在日本群马大学医学部获得医科学博士学位。

工作经历

2002年至2004年在南开大学分子生物学研究所担任助理工程师;

2009至2010年在日本群马大学医学部分子细胞药理系担任外国人研究员;

2010年至2014年在美国加州大学圣地亚哥分校细胞分子医学系做博士后研究;

2014年聘为湖南大学副教授。

学术兼职
参与评审了多个国际期刊的稿件。
论文专著
在Journal of American Society of Nephrology, American Journal of Physiology-Heart and Circulatory Physiology, Journal of Pharmacological Sciences 等多个国际期刊上发表了10余篇论文。

1.Wang H, Misaki T, Taupin V, Ghosh P, Farquhar MG. GIV/Girdin Links VEGF Signaling to Akt Survival Signaling in Podocytes . J Am Soc Nephrol, 26(2):314-27, 2015.

2.Zhang W, Lu Z, Kong G, Gao Y, Wang T, Wang Q, Cai N, Wang H, Liu F, Ye L, Zhang X. Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP. Mol Cancer. May 28;13:128, 2014

3.Wang H, Nakamura A, Yoshiyama S, Ishikawa R, Cai N, Ye LH, Takano-Ohmuro H, Kohama K. Down-regulation of myosin light chain kinase expression in vascular smooth muscle cells accelerates cell proliferation: requirement of its actin-binding domain for reversion to normal rates. J Pharmacol Sci 119(1):91-6, 2012.

4.Wang H, Nakamura A, Matsumoto A, Yoshiyama S, Qin X, Ye LH, Xe C, Zhang Y, Gao Y, Ishikawa R, Kohama K.. Non-kinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine. Am J Physiol Heart Circ Physiol 296: H1683-H1693, 2009.

5.Wang H, Tanaka H, Qin X, Zhao T, Ye L, Okagaki T, Katayama T, Nakamura A, Ishikawa R, Thatcher S, Wright G, and Kohama K. Blebbistatin Inhibits the Chemotaxis of Vascular Smooth Muscle Cells through Breaking the Interaction between Myosin II and Actin. Am J Physiol Heart Circ Physiol 294: H2060-H2068, 2008.

6.Garcia-Marcos M, Kietrsunthorn PS, Wang H, Ghosh P, Farquhar MG. G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs. J Biol Chem 12;286(32):28138-49, 2011.

7.Yoshiyama S, Horinouchi T, Miwa S, Wang H, Kohama K, Nakamura A. Effect of cigarette smoke components on vascular smooth muscle cell migration toward platelet-derived growth factor BB. . J Pharmacol Sci 115(4), 532–5, 2011.

8.Thatcher SE, Fultz ME, Tanaka H, Hagiwara H, Zhang HL, Zhang Y, Hayakawa K, Yoshiyama S, Nakamura A, Wang H, Katayama T, Watanabe M, Lin Y, Wright GL, Kohama K.Myosin light chain kinase/actin interaction in phorbol dibutyrate-stimulated smooth muscle cells. J Pharmacol Sci 116(1), 116–27, 2011.

9.Shen Z, Wei W, Tanaka H, Kohama K, Ma G, Dobashi T, Maki Y, Wang H, Bi J, Dai S. A galactosamine-mediated drug delivery carrier for targeted liver cancer therapy. Pharmacol Res 64(4), 410–9, 2011.

10.Watanabe M, Yumoto M, Tanaka H, Wang H, Katayama T, Yoshiyama S, Black J, Thatcher SE, Kohama K. Blebbistatin, a myosin II inhibitor, suppresses contraction and disrupts contractile filaments organization of skinned taenia cecum from guinea pig. Am J Physiol Cell Physiol 298:C1118-26, 2010.